In a bowl, combine together onion powder, garlic powder, oregano, vinegar, and lime juice. Add the chicken pieces and toss to coat. Cover and let marinate for at least 30 minutes.
Spread the flour in a shallow dish; season with salt and pepper. Thoroughly coat chicken pieces in the seasoned flour and shake off any excess before frying.
Heat oil in a large pan and fry chicken in batches, until browned and cooked through. Drain on paper towels and serve.